NIH Funding Announcement Calls for Sequential, Multiple Assignment, Randomized Trials (SMARTs)

January 17, 2013:
A new announcement from NIH seeks proposals that improve behavioral treatments for drug abuse, HIV, chronic pain, or related behaviors. PA-13-077 is sponsored by the National Institute on Drug Abuse (NIDA), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and the Office of Behavioral and Social Sciences Research (OBSSR). This program announcement specifically solicits proposals featuring sequential, multiple assignment, randomized trial (SMART) designs because of SMART’s applicability to efficacy studies and to translating interventions into real world settings.

SMART, an experimental design method for building adaptive health interventions, was developed by Methodology Center Principal Investigator Susan Murphy and her collaborators. Adaptive health interventions allow clinicians to create treatment sequences that change based on a patient’s characteristics or responses to earlier treatments. Adaptive interventions can improve outcomes for patients who are not responding to early treatments while decreasing burden and costs for patients who become stable during treatment. We are pleased by NIH’s recognition of how SMART designs can improve treatments and outcomes for patients.

View the program announcement

Read more about SMART

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