Funding Opportunities Calling for SMART, MOST, or JITAI

Researchers planning to write a proposal that incorporates a just-in-time adaptive intervention (JITAI) or sequential, multiple assignment, randomized trial (SMART) or that follows the multiphase optimization strategy (MOST) should review the NIH program announcements below. Each one calls for SMART, JITAI, or MOST designs.You may also want to review Linda Collins’ advice for planning a grant proposal using MOST.

NIH PAR-19-309 (originally issued as PAR-16-278 and previously reissued as NIH PAR-18-018) Stimulating Innovations in Behavioral Intervention Research for Cancer Prevention and Control (R21)

Agency
—  National Cancer Institute (NCI)

Purpose: “to provide support for the development of innovative interventions that improve cancer-related health behaviors across diverse racial/ethnic populations”

Designs specified: Just-in-time adaptive interventions (JITAIs), SMART, and MOST

Open PAR-19-309

NIH PAR-19-093 Leveraging Health Information Technology (Health IT) to Address Minority Health and Health Disparities (R01 Clinical Trial Optional)

Agencies
—  National Institute on Minority Health and Health Disparities (NIMHD)
—  National Cancer Institute (NCI)
—  National Institute of Biomedical Imaging and Bioengineering (NIBIB)

Purpose: “to examine how health information technology adoption impacts minority health and health disparity populations in access to care, quality of care, patient engagement, and health outcomes”

Designs specified: “Health information technology” are an ideal setting for MRT and JITAI

Open PAR-19-093

NIH PAR-18-892 & PAR-18-893 (originally issued as PA-16-122 & PA-16-123) Physical Activity and Weight Control Interventions Among Cancer Survivors: Effects on Biomarkers of Prognosis and Survival (R20/R21)

Agency
— 
 National Cancer Institute (NCI)

Purpose: “to stimulate transdisciplinary and translational research that will identify the specific biological or biobehavioral pathways through which physical activity and/or weight control may affect cancer prognosis and survival”

Designs specified: Suggested experimental designs include fractional factorial designs, which are frequently used in MOST.

Open PA-18-892
Open PA-18-893

NIH PAR-18-662 & PAR-18-663 Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Mind and Body Interventions (Collaborative UG3/UH3 Clinical Trial Required)

Agency
  National Center for Complementary and Integrative Health (NCCIH)

Purpose: “to study the effects of mind and body interventions in NCCIH designated areas of high research priority”

Designs specified: SMART and MOST

Open PAR-18-662 or PAR-18-663

NIH PAR-18-502 & PAR-18-503 Advancing the Science of Geriatric Palliative Care (R01 & R21 – Clinical Trial Optional)

Agencies
— 
 National Institute on Aging (NIA)
—  National Center for Complementary and Integrative Health (NCCIH)
—  National Institute of Nursing Research (NINR)
—  National Institute on Minority Health and Health Disparities (NIMHD)
—  National Cancer Institute (NCI)
—  National Heart, Lung, and Blood Institute (NHLBI)

Purpose: “to encourage research grant applications focused on palliative care in geriatric populations”

Designs specified: SMART and MOST

Open PAR-18-502 or PAR-18-503

NIH PAR-18-417 Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34  Clinical Trial Required)

Agency
  National Center for Complementary and Integrative Health (NCCIH)

Purpose: “to support early phase clinical trials of mind and body approaches for conditions that have been identified by NCCIH as high priority research topics”

Designs specified: SMART and MOST

Open PAR-18-417

NIH PA-18-383  (originally Issued as NIH PA-14-112) A Family-Centered Self-Management of Chronic Conditions  (R01)

Agency
 National Institute of Nursing Research (NINR)

Purpose: “to encourage research that seeks to build the science of family-centered self-management (FCSM) in chronic conditions”

Designs specified: MOST and SMART

Open PA-18-383

NIH PA-18-307 (Previously issued as PA-14-321)  Developing Interventions for Health-Enhancing Physical Activity (R21/R33)

Agencies
—  Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)
—  National Cancer Institute (NCI)
—  National Institute on Aging (NIA)
—  National Institute on Alcohol Abuse and Alcoholism (NIAAA)
—  National Center for Complementary and Alternative Medicine (NCCAM)
—  Office of Behavioral and Social Sciences Research (OBSSR)
—  Office of Research on Women’s Health (ORWH)

Purpose: “to support highly innovative research aimed at developing multi-level interventions that will increase health-enhancing physical activity…”

Designs specified: MOST and SMART

Open PA-18-307

NIH PAR-18-307 Developing Interventions for Health-Enhancing Physical Activity (R21/R33 – Clinical Trial Optional)

Agencies
— 
 Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)
—  National Cancer Institute (NCI)
—  National Institute on Aging (NIA)
—  National Institute on Alcohol Abuse and Alcoholism (NIAAA)
—  National Institute on Drug Abuse (NIDA)
—  National Center for Complementary and Integrative Health (NCCIH)

Purpose: “to fund highly innovative and promising research aimed at developing multi-level physical activity intervention programs designed to increase health-enhancing physical activity”

Designs specified: adaptive interventions and MOST

Open PAR-18-307

NIH PAR-18-118 (originally issued as NIH PAR-17-215) NCCIH Mind and Body Clinical Trial Cooperative Agreement (U01)

Agency
— 
National Center for Complementary and Integrative Health (NCCIH)

Purpose: “to develop and test adaptive interventions; optimize the intervention by evaluating which element of a complex intervention are critical for changes in outcome; assessing whether the intervention can be delivered with fidelity across sites in preparation for a future multi-site trial;…”

Designs specified: adaptive interventions and MOST

Open PAR-18-118

NIH PAR-18-086 (originally issued as PAR-16-353 Target Assessment, Engagement and Data Replicability to Improve Substance Use Disorders Treatment Outcomes (R21/R33)

Agencies
—  National Institute on Drug Abuse (NIDA)
—  National Cancer Institute (NCI)
—  National Institute of Alcohol Abuse and Alcoholism (NIAAA)

Purpose: “to generate and conduct preliminary tests of targeted addiction treatment to address multiple substances, which may include alcohol, tobacco and other drug use (ATOD)”

Designs specified: adaptive interventions and MOST

Open PAR-18-086

 

Previous Funding Opportunities

NIH PAR-18-385 & PAR-18-407 Population Health Interventions: Integrating Individual and Group Level Evidence (R01 & R21Clinical Trial Optional)

Agencies
—  National Cancer Institute (NCI)
—  National Institute on Deafness and Other Communication Disorders (NIDCD)
—  National Institute on Drug Abuse (NIDA)
—  Office of Behavioral and Social Sciences Research (OBSSR)

Purpose: “to support multilevel, transdisciplinary population health interventions that target underlying social, economic, and environmental conditions in an effort to improve health outcomes”

Designs specified: SMART and MOST

Open PAR-18-385 or PAR-18-407

This announcement is closed.

NIH PA-18-194 (Previously issued as PA-15-299) Alcohol Use Disorders: Treatment, Services, and Recovery Research (R01)

Agency
 National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Purpose: “to support research on behavioral and pharmacological treatment for alcohol use disorders…”

Designs specified: “adaptive clinical trial designs and statistical analyses that allow for adjustments to treatment based on the changing disease status of the patient.” This is SMART.

Open PA-18-194

This announcement is closed.

NIH PA 16-072 (Originally Issued as PA-13-077)  Behavioral and Integrative Treatment Program (R01)

Agencies
  National Institute on Drug Abuse (NIDA)
—  National Institute on Alcohol Abuse and Alcoholism (NIAAA)
—  National Center for Complementary and Alternative Medicine (NCCAM)
—  Office of Behavioral and Social Science Research (OBSSR)

Purpose: “to encourage behavioral intervention development research…”

Designs specified: SMART

Open PA-16-072

This announcement is closed.

NIH PA-15-036 Research Aimed at Novel Behavioral Targets to Improve Adolescent Substance Abuse Treatment and Prevention Interventions (R01)

Agencies
—  
National Institute on Drug Abuse (NIDA)
—  National Institute on Alcohol Abuse and Alcoholism (NIAAA)
—  National Cancer Institute (NCI)

Purpose: “to inform the generation and refinement of novel targets for substance abuse treatment and prevention interventions, modules or adjuncts to existing treatments, and prevention interventions that seek to target and modulate behavioral or neurobehavioral processes in adolescents “

Designs specified: MOST and “adaptive designs” which are used in SMARTs

Open PA-15-036

This announcement is closed.

IES CDFA 84.324A Special Education Research Grants Request for Applications

Agency
—  Institute of Education Sciences at the Department of Education

Purpose: “…to expand the knowledge base and understanding of infants, toddlers, children, and youth with disabilities through advancing the understanding of and practices for teaching, learning, and organizing education systems.”

Designs specified: SMART “Researchers are encouraged to consider the development of high-quality adaptive interventions, or individually tailored treatments.”

Open Expired CFDA 84.324A

This announcement is closed.

NIH PA-13-165  Innovative Research Methods: Prevention and Management of Symptoms in Chronic Illness (R01)

Agencies
—  National Institute of Nursing Research (NINR)
—  National Cancer Institute (NCI)

Purpose: “to update the randomized control trial design using novel research methods”

Designs specified: SMART and MOST

Open Expired PA-13-165

This announcement is closed.

NIH PA-11-063 Translating Basic Behavioral and Social Science Discoveries into Interventions to Improve Health-Related Behaviors (R01)

Agencies
—  Office of Behavioral and Social Science Research (OBSSR)
—  National Cancer Institute (NCI)
—  National Center for Complementary and Alternative Medicine (NCCAM)
—  National Heart, Lung, and Blood Institute (NHLBI)
—  National Institute on Alcohol Abuse and Alcoholism (NIAAA)
—  Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
—  National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
—  National Institute on Drug Abuse (NIDA)
—  Office of Research on Women’s Health (ORWH)

Purpose: “developing and refining novel behavioral interventions with high potential impact to improve health-promoting behaviors, and/or reduce problem health behaviors (e.g., smoking, tanning or physical activity or alcohol or substance use, abuse or dependence)”

Designs specified: “Studies using adaptive designs, fractional factorial experiments and pre-specified decision rules based on participant characteristics and responses to treatment…” This indicates SMART or MOST.

Open Expired PA-11-063

This announcement is closed.

IES CDFA 84.324A Special Education Research Grants Request for Applications


Agency
—  Institute of Education Sciences at the Department of Education

Purpose: “…to expand the knowledge base and understanding of infants, toddlers, children, and youth with disabilities through advancing the understanding of and practices for teaching, learning, and organizing education systems.”

Designs specified: SMART “Researchers are encouraged to consider the development of high-quality adaptive interventions, or individually tailored treatments.”

This announcement is closed.