Recommended Reading for Optimizing Behavioral Interventions

Please note that the following books are available for free PDF download through many universities’ libraries.

Collins, L.M. (2018). Optimization of behavioral, biobehavioral, and biomedical interventions: The multiphase optimization strategy (MOST). New York: Springer.

Collins, L.M., & Kugler, K.C. (2018). Optimization of Behavioral, Biobehavioral, and Biomedical Interventions: Advanced Topics.  New York: Springer.

 

Introduction

Collins, L.M. (2018). Optimization of behavioral, biobehavioral, and biomedical interventions: The multiphase optimization strategy (MOST). New York: Springer.

Collins, L. M., Kugler, K. C., & Gwadz, M. V. (2015). Optimization of multicomponent behavioral and biobehavioral interventions for the prevention and treatment of HIV/AIDS. Aids Behavior, Supp 1, 197-214.

 

Some Implementations of MOST

These articles describe the thinking behind some implementations of MOST or related approaches in field settings. These examples all describe factorial optimization trials, although other experimental designs are often used for optimization trials.

Baker, T. B., Collins, L. M., Mermelstein, R., Piper, M. E., Schlam, T. R., Cook, J. W., et al. (2016). Enhancing the effectiveness of smoking treatment research: conceptual bases and progress. Addiction, 111(1)., 107-16. doi:10.1111/add.13154

Bernstein, S.L., Dziura, J., Weiss, J., Miller, T., Vickerman, K.A., Grau, L.E., Pantalon, M.V., Abroms, L., Collins, L.M., & Toll, B. (2018). Tobacco dependence treatment in the emergency department: A randomized trial using the multiphase optimization strategy. Contemporary Clinical Trials, 66, 1-8. PMCID: PMC5851600

Celano, C.M., Albanese, A., Millstein, R.A., Mastromauro, C.A., Chung, W.-J., Legler, S., Park, E.R, Healy, B.C., Collins, L.M., Januzzi, J.L., & Huffman, J.C. (2018). Optimizing a positive psychology intervention to promote health behaviors following an acute coronary syndrome: The Positive Emotions after Acute Coronary Events-III (PEACE-III) randomized factorial trial. Psychosomatic Medicine, 80, 526-534. PMCID: PMC6023730

Cook, J. W., Collins, L. M., Fiore, M. C., Smith, S. S., Fraser, D., Bolt, D. M., et al. (2016). Comparative effectiveness of motivation phase intervention components for use with smokers unwilling to quit: a factorial screening experiment. Addiction, 111(1)., 117-28. doi:10.1111/add.13161

Gwadz, M.V., Collins, L.M., Cleland, C.M., Leonard, N.R., Wilton, L., Gandhi, M., Braithwaite, R.S., Perlman, D.C., Kutnick, A., & Ritchie, A.S. (2017). Using the multiphase optimization strategy (MOST) to optimize an HIV care continuum intervention for vulnerable populations: A study protocol. BMC Public Health, 17, 383. PMCID: PMC5418718

Kugler, K. C., Wyrick, D. L., Tanner, A. E., Milroy, J. J., Chambers, B., Ma, A., Guastaferro, K. M., and Collins L. M. (2018). Using the multiphase optimization strategy (MOST) to develop an optimized online STI preventive intervention aimed at college students: Description of conceptual model and iterative approach to optimization.  In Collins, L. M., & Kugler, K. C. Optimization of Behavioral, Biobehavioral, and Biomedical Interventions: Advanced Topics.  New York: Springer, pp. 1—21.

McClure, J. B., Derry, H., Riggs, K. R., Westbrook, E. W., St. John, J., Shortreed, S. M., Bogart, A., & An, L. C. (2012). Questions about quitting (Q(2)): Design and methods of a Multiphase Optimization Strategy (MOST) randomized screening experiment for an online, motivational smoking cessation intervention. Contemporary Clinical Trials, 33(5), 1094-1102. PMCID: PMC3408878

Pellegrini, C.A., Hoffman, S.A., Collins, L.M., & Spring, B. (2014).  Optimization of remotely delivered intensive lifestyle treatment for obesity using the multiphase optimization strategy:  Opt-IN study protocol.  Contemporary Clinical Trials. NOTE: See important corrigendum {Pellegrini, C. A., Hoffman, S. A., Collins, L. M., & Spring, B. (2015). Corrigendum to “Optimization of remotely delivered intensive lifestyle treatment for obesity using the multiphase optimization strategy: Opt-IN study protocol” [Contemp. Clin. Trials 38 (2014) 251–259]. Contemporary Clinical Trials, 45, 468 – 469. doi:10.1016/j.cct.2015.09.001}

Piper, M. E., Fiore, M. C., Smith, S. S., Fraser, D., Bolt, D. M., Collins, L. M., et al. (2016). Identifying effective intervention components for smoking cessation: a factorial screening experiment. Addiction, 111(1)., 129-41. doi:10.1111/add.13162

Schlam, T. R., Fiore, M. C., Smith, S. S., Fraser, D., Bolt, D. M., Collins, L. M., et al. 2016). Comparative effectiveness of intervention components for producing long-term abstinence from smoking: a factorial screening experiment. Addiction, 111(1)., 142-55. doi:10.1111/add.13153

Watkins, E., Newbold, A., Tester-Jones, M., Javaid, M., Cadman, J., Collins, L.M., Graham, J., & Mostazir, M. (2016). Implementing multifactorial psychotherapy research in online virtual environments (IMPROVE-2): Study protocol for a phase III trial of the MOST randomized component selection methods for internet cognitive-behavioural therapy for depression. BMC Psychiatry, 16, 345. PMCID: PMC5054552

 

Rationale for factorial optimization trials

These articles review practical aspects of experimental design relevant to intervention science and attempt to correct some pervasively held misconceptions. These articles and may be useful as citations.

Collins, L.M. (2018). Chapter 3 in Optimization of behavioral, biobehavioral, and biomedical interventions: The multiphase optimization strategy (MOST). New York: Springer.

Collins, L.M., Dziak, J.J., Kugler, K.C., & Trail, J.B. (2014).  Factorial experiments: Efficient tools for evaluation of intervention components. American Journal of Preventive Medicine47, 498-504.

Collins, L. M., Dziak, J. J., & Li, R. (2009). Design of experiments with multiple independent variables: A resource management perspective on complete and reduced factorial designs. Psychological Methods,14(3), 202-224. PMCID: PMC2796056

Advanced topics in factorial optimization trials

Chakraborty, B., Collins, L. M., Strecher, V., & Murphy, S. A. (2009). Developing multicomponent interventions using fractional factorial designs. Statistics in Medicine 28, 2687-2708. PMCID: PMC2746448

Dziak, J. J., Nahum-Shani, I., & Collins, L. M. (2012). Multilevel factorial experiments for developing behavioral interventions:  Power, sample size, and resource considerations. Psychological Methods, 17, 153. PMCID: PMC3351535

Nair, V., Strecher, V., Fagerlin, A., Ubel, P., Resnicow, K., Murphy, S. A., Little, R., Chakraborty, B., & Zhang, A. (2008). Screening experiments and the use of fractional factorial designs in behavioral intervention research. American Journal of Public Health,98, 1354-1359. PMCID: PMC2446451

 

Design of Adaptive Interventions

Collins, L.M., Murphy, S.A., & Bierman, K. (2004). A conceptual framework for adaptive preventive interventions. Prevention Science, 3, 185-196.

Nahum-Shani, I., Smith, S. N., Spring, B.J., Collins, L.M., Witkiewitz, K., Tewari, A., & Murphy, S. A. (2018). Just–in-time adaptive interventions (JITAIs) in mobile health: Key components and design principles for ongoing health behavior support. Annals of Behavioral Medicine, 52, 446-452. PMCID: PMC5364076

Riley, W. T., Serrano, K. J., Nilsen, W., & Atienza, A. A. (2015). Mobile and wireless technologies in health behavior and the potential for intensively adaptive interventions. Current Opinion in Psychology, 5, 67–71.

 

Experimental Designs Useful in Optimization of Adaptive Interventions

Almirall, D., Nahum-Shani, I., Wang, L., & Kasari, C. (2018).  Experimental designs for research on adaptive interventions: Singly and sequentially randomized trials.  In Collins, L. M., & Kugler, K. C. Optimization of Behavioral, Biobehavioral, and Biomedical Interventions: Advanced Topics.  New York: Springer, pp. 89—120.

Collins, L. M., Nahum-Shani, I., & Almirall, D. (2014). Optimization of behavioral dynamic treatment regimens based on the sequential, multiple assignment, randomized trial (SMART). Clinical Trials, 11, 426-434. PMCID: PMC4257903

Dong, Y., Rivera D.E., Downs, D.S., Savage, J.S., Thomas, D.M., & Collins, L.M. (2013). Hybrid model predictive control for optimizing gestational weight gain behavioral interventions. Proceedings from the 2013 American Control Conference. 1970-1975. PMCID: PMC3856197.

Rivera, D. E., Hekler, E. B., Savage, J. S., and Symons Downs D. (2018). Intensively adaptive interventions using control systems engineering: Two illustrative examples.  In Collins, L. M., & Kugler, K. C. Optimization of Behavioral, Biobehavioral, and Biomedical Interventions: Advanced Topics.  New York: Springer, pp. 89—120.

Timms, K.P., Rivera, D.E., Collins, L.M., & Piper, M.E. (2014). Continuous-time system identification of a smoking cessation intervention. International Journal of Control, 87, 1423-1437.

Timms, K. P., Rivera, D. E., Collins, L. M., & Piper, M. E. (2013).  A dynamical systems approach to understand self-regulation in smoking cessation behavior change. Nicotine and Tobacco Research, 16, S159-168.

 

Practical considerations

Gallis, J. A., Bennett, G. G., Steinberg, D. M., Askew, S., & Turner, E. L. (2019). Randomization procedures for multicomponent behavioral intervention factorial trials in the multiphase optimization strategy framework: challenges and recommendations. Translational behavioral medicine, 9(6), 1047-1056.

Huffman, J.C., Millstein, R.A., Celano, C.M., Healy, B.C., Park, E.R., & Collins, L.M. (2019). Developing a psychological-behavioral intervention in cardiac patients using the multiphase optimization strategy: Lessons learned from the field. Annals of Behavioral Medicine. doi: 10.1093/abm/kaz035

Piper, M. E., Schlam, T. R., Fraser, D., Oguss, M., & Cook, J. W. (2018).  Implementing factorial experiments in real-world settings: Lessons learned while engineering an optimized smoking cessation treatment.  In Collins, L. M., & Kugler, K. C. Optimization of Behavioral, Biobehavioral, and Biomedical Interventions: Advanced Topics.  New York: Springer, pp. 23—45.

Wyrick, D.L., Rulison, K.L., Fearnow-Kenney, M., Milroy, J.J., & Collins, L.M. (2014).  Moving beyond the treatment package approach to developing behavioral interventions: Addressing questions that arose during an application of the multiphase optimization strategy (MOST). Translational Behavioral Medicine, 4, 252-259.

 

Last update: 2020