Podcast: New Book on Advanced Topics in MOST

August 8, 2018:lc18karik
In podcast 33, Methodology Center Director Linda Collins and Faculty Affiliate Kari Kugler discuss the new book from Springer that they edited, Optimization of Behavioral, ​Biobehavioral, and Biomedical Interventions: Advanced Topics. This is the second book on the multiphase optimization strategy (MOST) to be published this year. MOST is an engineering-based framework for optimizing interventions that has been developed by Linda and her collaborators over the past 14 years. In this podcast, Linda and Kari explain the concepts behind and rationale for each of the chapters in the book. Both the book and the podcast explore topics ranging from the development of a conceptual model to the use of concepts from control systems engineering.

Download podcast 33

Download podcast 31 (about the introductory MOST book).


00:00 – Introduction
01:08 – The differences between the two books on MOST
02:19 – Developing a conceptual model for an intervention
04:54 – Factorial experiments and types of experimental designs
08:35 – Multi-level factorial designs
10:11 – Adaptive interventions and MOST
11:38 – Control systems engineering in MOST
13:29 – Coding data for analysis
16:00 – Cost effectiveness analysis in MOST
18:25 – Mediation analysis in MOST
20:00 – The future of MOST


Collins, L. M., & Kugler, K. C. (2018). Optimization of behavioral, biobehavioral, and biomedical interventions: Advanced topics. New York, NY: Springer.

Collins, L. M. (2018). Optimization of behavioral, biobehavioral, and biomedical interventions: The multiphase optimization strategy (MOST). New York, NY: Springer.